Mind Map Gallery Colorectal Cancer

Colorectal Cancer

This is a mind map that contains information about colorectal cancer. Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine).

Edited at 2020-10-08 07:57:34

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Colorectal Cancer

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Outline

Colorectal Cancer

Pathology

Progression from 1st abnormal cell to CRChappens over a 10 15 year period.

High risk polyp findings include multiplepolyps, villous polyps, and larger polyps;

Multiple geenetic and environmentalfactors have been linked to thedevelopment of CRC.

Information

CRC is a neoplasm that develops in thecolon or rectum.

CRC is the 2nd leading cause of cancerrelated deaths and the 3rd most commoncancer.

The life time risk of developing CRC, in theUS, is about 1 in 21 (4.8%)

In 2014, in the US, there were 96,830 newcases of colon cancer; 40,000 new cases ofrectal cancer.

Diets high in fruits and vegetables havebeen linked with decreased risk.

Treatment

Primary Treatment: Surgical resection

Other surgical options include:hemicolectomy, or colectomy, withnoderesection depending on size and invasion.

Surgery for rectal cancer may include localtransanal, low anterior, orabdominoperianal resection

Radiation therapy is most often used forperitoneal or rectal cancers.

1st Line medication: CombinationChemotherapy which may include oxaliplatin, irinotecan, fluorouracil,leucovorin, and capectabine.

2nd line medication: May use along with1st line medications or alone if 1st linemedications do not work.

Bevacizumab (Avastin) a monoclonalantibody that targets vascular endothelialgrowth factor; inhibits angiogensis.

Cetuximab (Erbitux) and panitumumab(Vectibix) monoclonal antobodies thattarget epidermal growth factor receptors.

Aflibercept and regorafenib are neweragents with actions on vascularendothelial growth factor.

Treatment

Primary Treatment: Surgical resection

Other surgical options include:hemicolectomy, or colectomy, withnoderesection depending on size and invasion.

Surgery for rectal cancer may include localtransanal, low anterior, orabdominoperianal resection or pelvicexenteration.

Radiation therapy is most often used forperitoneal or rectal cancers; it is also usedto relieve symptoms.

1st Line medication: CombinationChemotherapy which may include oxaliplatin, irinotecan, fluorouracil,leucovorin, and capectabine.

2nd line medication: May use along with1st line medications or alone if 1st linemedications do not work.

Bevacizumab (Avastin) a monoclonalantibody that targets vascular endothelialgrowth factor; inhibits angiogensis.

Cetuximab (Erbitux) and panitumumab(Vectibix) monoclonal antobodies thattarget epidermal growth factor receptors.

Aflibercept and regorafenib are neweragents with actions on vascularendothelial growth factor.