Immunology

Immunology
signalling
cytokines
antiinflammatory
IL10
TGF beta
IL2
inflammatory
TNF
targets
IL 1
IL 6
targets
IL 12
IFN Gamma
IL 8
IL15
IFN type 1
Chemokines
Lymph node localisation
CCL19 & CCL21
CXCL5
recruitment into the infection site
CCL2
CCL11
CXCL8
CCL5
CCL3
homing of naive T and B cells
Lipid mediators
inflammatory
Prostaglandins (PGI2)
Leukotrienes
Platelet activating factor
Antiinflammatory
Glucocorticoids
Cortisol
Vasoactive amines
Histamine
co stimulation
B cell to T cell
CD40
Antigen presenting cell to T cell
Inhibitory
CTLR4
Activating
CD28
Intracellular signalling
initiation
general principles
1) Receptor Activation
2) Tyrosine Kinase (TK) Activation
TK Structure
3) Transcription factors
BCR, TCR and TLR
TCR complex
Mechanism
BCR complex
Mechanism
regulation of TCR / BCR signaling
TLR Mechanism
Adaptive
B cells
B cell receptor
Co receptors
Ig alpha
Ig beta
Bcell development
Bone marrow
Ig gene rearrangement V(D)J
recombination
Antibody production
IgM
IgG
IgA
IgE
T cells
T cell development
1. Bonemarrow
2. Thymus
3. Activation and proliferation in
peripheral tissues
CD4+ Th cells
T cell subsets
Treg
Natural FOXP3+ Treg
Inducible iTreg
CD4+
TH17
TH1
TH2
T(FH)
CD8+
Cytotoxic T cells
gamma delta T cells
T cell receptor
Co receptors
CD3
Zeta
Disorders
Hypersensitivity
Type I: IgE mediated
Anaphylaxis
Allergy
Atopy
Allergic Asthma
Type II: IgM and IgG mediated
Type III: immune complex mediated
type IV: T cell mediated
multiple sclerosis
type I diabetes
contact sensitivity
Cancer
Tumour Antigens
Vaccines against oncogenic DNA Viruses
Immune responses against cancer
NK cells
Macrophages
CD8+ T cells
Autoimmunity
Medical Approach
vaccines
Features
Example: peptide vaccines
Adjuvants
Example: Hep B
Transplant
Tissue matching
Immunosuppression
Azathioprine
Corticosteriods
CyclosporinA
Sirolimus
Evolution of the Immune system
Deutrostromes
Jawless vertebrates
Innate and acquired immunity
Jawed vertebrates
Innate and novel acquired immunity
Protosomes
Innate immunity
immune tissue
Primary
Bone Marrow
fetal liver
Thymus
Seconday
Lymph nodes
Spleen
Peyers patch
Peripheral tissue
mucosal immune tissues
Innate
Cellular
Granulocyte
Neutrophils
Basophils
Eosinophils
histamine & leukotriene
Mast cells
Monocytes
Macrophage
Dendritic
innatelike lymphocytes
Natural Killer NK cells
perforin
B1 cells
epithelial gamma:delta cells
NK T cells
Non Cellular
Lysozyme
defensins
Transferrin
opsinisaton and complement
activating proteins
Pentraxins
Collectins
Ficollins
Complement
Natural Antibodies
localisation
Adhesion
integrin
LFA1
Also help cell to cell adhesion
for MHC sampling
selectin
Eselectin
Pselectin
Lselectin
Pathogens
Parasites
Trypanosomai Brucei
Schitosomiasis spp.
fungal infection
Aspergillus Fumigatus
Cryptococcus neoformans
Candida Albicans
Immune responses against
fungal infections
Viruses
Innate immune response
IFN type I
NK cells
Adaptive immune response
Antibodies
Cytotoxic T cells
Retroviruses
Human T lymphotropic VIrus (HTLV) 1
Human Immunodeficiency Virus (HIV)
108 1 1