autonomic nervous system

Autonomic Nervous SystemParasympathomimeticsCholinergic AntagonistsAdrenergic AntagonistsAdrenergic AgonistsAllergiesCardiac, vascular conditionsBronchial asthmaPremature labourMydriatic, hypoglycemiaParasympathomimeticsCholinergic AntagonistsAdrenergic AntagonistsAdrenergic AgonistsAllergiesCardiac, vascular conditionsBronchial asthmaPremature labourMydriatic, hypoglycemiaCholine EstersCholinomimetic AlkaloidsAntimuscarinic AgentsGanglionic BlockersTarget Nn-receptorsNeuromuscular BlockersTarget Nm-receptorsB-receptorsa-receptorsCholinesterase InhibitorsPrevents binding of ACh to AChEReduces rate of hydrolysis, increases cholinergic effectsForm intermediates with ACE, or act as pure competitive inhibitorsPharmacological EffectsDigestive TractIncrease GI motility, peristalsisIncrease frequency and strength of peristalisis: defecationOcular EffectsPupillary constriction, spasm of accomodationSkeletal MuscleAnticurare agentsDepolarizing agents - stimulating effectGanglionic stimulation, hypotension, bradycardia, arrhythmiaContraction of bladder, bronchoconstrictionToxicologyContraindicated for impaction with obstruction, pregnancyPupil constriction, dyspnea, bradycardia, hypotensionRespiratory paralysis + increased bronchiolar secretion (death)Neostigmine: skeletal muscle weakness, nausea, vomiting, colic, diarrheaPhysostigmine: stimulation followed by CNS depression, convulsionsTreatment: Atropine
7